The first interaction with Europeans the Pawnee had was in the 16th century. Francisco Vasquez de Coronado led Spanish explorers on an expedition. They were probably astonished to see men with hairy faces and metal armor. They took new animals brought by the Spanish. The horses enlarged the hunting area, made travel easier, and made work easier.
The Europeans brought small pox, cholera, measles, tuberculosis, and many other diseases to the Pawnee Indians. This caused a great decrease in their population.
Soon, Napoleon Bonaparte sold the land to the American settlers. The Pawnee began to have disagreements with the
Americans.
The Spanish brought horses to the Pawnee when they came to American on explorations.